{"id":6128326,"date":"2014-05-06T21:14:03","date_gmt":"2014-05-06T19:14:03","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2014\/05\/06\/mire_jo_a_gmo_9_a_kolera"},"modified":"2014-05-06T21:14:03","modified_gmt":"2014-05-06T19:14:03","slug":"mire_jo_a_gmo_9_a_kolera","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=6128326","title":{"rendered":"Mire j\u00f3 a GMO? 9. – A kolera"},"content":{"rendered":"

\"kolera.jpg\"A v\u00e9d\u0151olt\u00e1sok l\u00e9te az orvostudom\u00e1ny egyik legnagyobb eredm\u00e9nye. A k\u00e9rd\u00e9s az, hogy lehetne -e m\u00e9g jav\u00edtani rajtuk valamit? Az els\u0151 \u00e9s k\u00e9zenfekv\u0151 megold\u00e1s, hogy b\u00e1r a jelenlegi v\u00e9d\u0151olt\u00e1sokat injekci\u00f3st\u0171vel adj\u00e1k be, ezzel az eg\u00e9sz szervezetre kiterjed\u0151 hat\u00e9kony ellenanyagv\u00e1laszt v\u00e1ltanak ki, de meg lehet -e oldani injekci\u00f3 n\u00e9lk\u00fcl? Az or\u00e1lis v\u00e9d\u0151olt\u00e1sokat, mint a nyelv\u00fck is mutatja, sz\u00e1jon \u00e1t adj\u00e1k \u00e9s hat\u00e9kony immunv\u00e1laszt v\u00e1ltanak ki a ny\u00e1lkah\u00e1rty\u00e1kon. A v\u00e9d\u0151olt\u00e1sok m\u00e1sik h\u00e1tr\u00e1nya, hogy \u00e1ltal\u00e1ban h\u0171tve kell \u0151ket t\u00e1rolni, ami sok harmadik vil\u00e1gbeli orsz\u00e1gban nehezen megoldhat\u00f3, nyilv\u00e1n ezek l\u00e9nyegesen olcs\u00f3bbak lenn\u00e9nek, ha nem kellene \u0151ket h\u0171teni.<\/p>\n

Nyilv\u00e1n sz\u00e1mos el\u0151nye lenne annak, ha a v\u00e9d\u0151olt\u00e1sokat n\u00f6v\u00e9nyekben lehetne el\u0151\u00e1ll\u00edtani, p\u00e9ld\u00e1ul eleve l\u00e9nyegesen olcs\u00f3bbak lehetn\u00e9nek, hiszen nem kellene \u0151ket tiszt\u00edtani \u00e9s h\u0171teni, nem kellene hozz\u00e1juk injekci\u00f3s t\u0171 \u00e9s fecskend\u0151 sem.<\/p>\n

Yoshizaku Yuki \u00e9s munkat\u00e1rsai a m\u00e1r ismertetett MucoRice<\/a> rendszerhez ny\u00faltak, ezzel rizsben termeltett\u00e9k meg meg a kolera toxin B alegys\u00e9g\u00e9t. Kipr\u00f3b\u00e1lt\u00e1k, legal\u00e1bb m\u00e1sf\u00e9l \u00e9vig h\u0171t\u00e9s n\u00e9lk\u00fcl is meg\u0151rzi a min\u0151s\u00e9g\u00e9t az \u00edgy termelt rizs, teh\u00e1t a harmadik vil\u00e1g orsz\u00e1gaiban is k\u00f6nny\u0171szerrel eltarthat\u00f3. Mivel a kolera toxin B alegys\u00e9ge \u00f6nmag\u00e1ban is immunv\u00e1laszt v\u00e1lt ki, er\u0151s adjuv\u00e1ns, \u00edgy egyebet nem is kellett a rizshez adni az immuniz\u00e1l\u00e1shoz.<\/p>\n

Kipr\u00f3b\u00e1lt\u00e1k mi t\u00f6rt\u00e9nik, hogy ha egereket ezzel a MucoRice-CTB -vel immuniz\u00e1lnak, majd kolera toxint etetnek vel\u00fck? Nem meglep\u0151 m\u00f3don az immuniz\u00e1latlan egereknek nagyon er\u0151sen menni kezdett a hasa, az immuniz\u00e1lt egereknek pedig csak nagyon kev\u00e9ss\u00e9. Ez l\u00e1that\u00f3 az \u00e1br\u00e1n, a fekete oszlopok az egerek bel\u00e9b\u0151l t\u00e1voz\u00f3 hasmen\u00e9s mennyis\u00e9g\u00e9t \u00e1br\u00e1zolj\u00e1k, ezek alapj\u00e1n \u00fagy t\u0171nik, hogy a MucoRice-CTB v\u00e9d a koler\u00e1t\u00f3l. Term\u00e9szetesen az elterjed\u00e9se el\u0151tti legf\u0151bb akad\u00e1ly, hogy bizony ez GMO -nak sz\u00e1m\u00edt, \u00edgy a vil\u00e1g egy jelent\u0151s r\u00e9sz\u00e9n eleve sohasem kap majd termeszt\u00e9si enged\u00e9lyt.<\/p>\n

\n

Yuki, Y., Tokuhara, D., Nochi, T., Yasuda, H., Mejima, M., Kurokawa, S., … & Kiyono, H.<\/strong> (2009). Oral MucoRice expressing double-mutant cholera toxin A and B subunits induces toxin-specific neutralising immunity. Vaccine<\/em>, 27(43)<\/strong>, 5982-5988.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A v\u00e9d\u0151olt\u00e1sok l\u00e9te az orvostudom\u00e1ny egyik legnagyobb eredm\u00e9nye. A k\u00e9rd\u00e9s az, hogy lehetne -e m\u00e9g jav\u00edtani rajtuk valamit? Az els\u0151 \u00e9s k\u00e9zenfekv\u0151 megold\u00e1s, hogy b\u00e1r a jelenlegi v\u00e9d\u0151olt\u00e1sokat injekci\u00f3st\u0171vel adj\u00e1k be, ezzel az eg\u00e9sz szervezetre kiterjed\u0151 hat\u00e9kony ellenanyagv\u00e1laszt v\u00e1ltanak ki, … Egy kattint\u00e1s ide a folytat\u00e1shoz…. →<\/span><\/a><\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,4,1],"tags":[8,36,6],"class_list":["post-6128326","post","type-post","status-publish","format-standard","hentry","category-elet_es_tudomany","category-gmo_vita","category-uncategorized","tag-biobulvar","tag-biodizajn","tag-gensebeszet"],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/6128326","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=6128326"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/6128326\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=6128326"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=6128326"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=6128326"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}