{"id":5006006,"date":"2011-04-17T21:28:13","date_gmt":"2011-04-17T19:28:13","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2011\/04\/17\/rancbol_a_laz"},"modified":"2011-04-17T21:28:13","modified_gmt":"2011-04-17T19:28:13","slug":"rancbol_a_laz","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5006006","title":{"rendered":"R\u00e1ncb\u00f3l a l\u00e1z"},"content":{"rendered":"<p><img decoding=\"async\" class=\"blossom-image-align-right\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/shar_pei.jpg\" alt=\"\" \/>A K\u00edn\u00e1b\u00f3l sz\u00e1rmaz\u00f3 <a href=\"http:\/\/hu.wikipedia.org\/wiki\/Shar_pei\">shar pei <\/a>kutyafajta azonnal felismerhet\u0151 r\u00e1ncos b\u0151r\u00e9r\u0151l. Hogy sz\u00f6veti szinten a r\u00e1ncok m\u00f6g\u00f6tt a b\u0151rben felgy\u00fcleml\u0151 <a href=\"http:\/\/en.wikipedia.org\/wiki\/Hyaluronan\">hyaluronsav<\/a> van, azt m\u00e1r r\u00e9gebb \u00f3ta tudjuk, de nem volt vil\u00e1gos, hogy mi az, ami ennek a kialakul\u00e1s\u00e1hoz vezet.<\/p>\n<p>A <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">kutyagenom<\/a> megszekven\u00e1l\u00e1sa \u00f3ta, azonban <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">szinte<\/a> <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">\u00f6z\u00f6nlenek<\/a> <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">a k\u00fcl\u00f6nb\u00f6z\u0151<\/a> <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">kutyafajt\u00e1k<\/a> <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201104\/\">trademark<\/a> jegyeinek genetikai okait felgomboly\u00edt\u00f3 tanulm\u00e1nyok, \u00edgy nem meglep\u0151, hogy a shar peiek titka sem sok\u00e1ig v\u00e1ratott mag\u00e1ra.<\/p>\n<p>A mut\u00e1ci\u00f3 (nem meglep\u0151 m\u00f3don) egy hyaluronsav szint\u00e9zis\u00e9rt felel\u0151s enzimhez, a <em>hyaluronan synthase 2 <\/em>(<em>HAS2<\/em>)-h\u00f6z k\u00f6thet\u0151, pontosabban annak egy szab\u00e1lyoz\u00f3 mut\u00e1ci\u00f3ja. A mut\u00e1ci\u00f3 fizikai val\u00f3j\u00e1ban egy duplik\u00e1ci\u00f3, pontosabban n\u00e9ha nem csak egy, hanem a sz\u00f3ban forg\u00f3 g\u00e9nszakasz id\u0151nk\u00e9nt ak\u00e1r 6x, vagy extr\u00e9mebb esetekben 15x is jelen lehet. Ez pedig ott v\u00e1lik \u00e9rdekess\u00e9, hogy min\u00e9l nagyobb ez a sz\u00e1m, ann\u00e1l nagyobb a\u00a0 val\u00f3sz\u00edn\u0171s\u00e9ge, hogy a kutyus szenved\u0151 alanya a fajt\u00e1ra jellemz\u0151 <a href=\"http:\/\/en.wikipedia.org\/wiki\/Shar_Pei_fever\">l\u00e1zzal j\u00e1r\u00f3 autoimmun betegs\u00e9gnek<\/a>.<\/p>\n<p>Ugyan a <em>HAS2<\/em> kifejez\u0151d\u00e9se \u00e9s a duplik\u00e1ci\u00f3 k\u00f3piasz\u00e1ma k\u00f6zti \u00f6sszef\u00fcgg\u00e9s nem felt\u00e9tlen\u00fcl line\u00e1ris (vagyis nagyobb k\u00f3piasz\u00e1m nem mindig jelent magasabb expresszi\u00f3t), a l\u00e1z maga m\u00e9gis a nagyobb HAS2<em> <\/em>koncentr\u00e1ci\u00f3val lehet \u00f6sszef\u00fcgg\u00e9sben: a hyaluronsav elt\u00f6redez\u00e9se sor\u00e1n keletkez\u0151 fragmensek beind\u00edtj\u00e1k a gyullad\u00e1sos immunv\u00e1laszt, \u00edgy nem kell sok logika, hogy arra jussunk, a nagyobb mennyis\u00e9g\u0171 hyaluronsav term\u00e9szetes leboml\u00e1s\u00e1val keletkez\u0151 t\u00f6red\u00e9kek lehetnek a ludasak a shaiper-l\u00e1z kialakul\u00e1s\u00e1ban is.<\/p>\n<hr \/>\n<p><span style=\"font-size: xx-small;\"><strong>Olsson M, Meadows JRS, Truv\u00e9 K, Rosengren Pielberg G, Puppo F, et al.<\/strong> (2011) A Novel Unstable Duplication Upstream of HAS2 Predisposes to a Breed-Defining Skin Phenotype and a Periodic Fever Syndrome in Chinese Shar-Pei Dogs. <em>PLoS Genet<\/em> <strong>7(3)<\/strong>: e1001332. doi:<a href=\"http:\/\/dx.doi.org\/10.1371\/journal.pgen.1001332\">10.1371\/journal.pgen.1001332<\/a> <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A K\u00edn\u00e1b\u00f3l sz\u00e1rmaz\u00f3 shar pei kutyafajta azonnal felismerhet\u0151 r\u00e1ncos b\u0151r\u00e9r\u0151l. Hogy sz\u00f6veti szinten a r\u00e1ncok m\u00f6g\u00f6tt a b\u0151rben felgy\u00fcleml\u0151 hyaluronsav van, azt m\u00e1r r\u00e9gebb \u00f3ta tudjuk, de nem volt vil\u00e1gos, hogy mi az, ami ennek a kialakul\u00e1s\u00e1hoz vezet. A kutyagenom &hellip; <a href=\"https:\/\/criticalbiomass.hu\/?p=5006006\">Egy kattint\u00e1s ide a folytat\u00e1shoz&#8230;. <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5006006","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5006006","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5006006"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5006006\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5006006"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5006006"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5006006"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}