{"id":5005913,"date":"2010-05-20T21:43:38","date_gmt":"2010-05-20T19:43:38","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2010\/05\/20\/szintetikus_elet_1_0"},"modified":"2021-04-03T09:12:06","modified_gmt":"2021-04-03T09:12:06","slug":"szintetikus_elet_1_0","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5005913","title":{"rendered":"Szintetikus \u00e9let 1.0"},"content":{"rendered":"

\"\"A „mir\u0151l \u00edrn\u00e9k, ha \u00e9pp lenne id\u0151m<\/em>” sorozat \u00fajabb darabj\u00e1hoz \u00e9rt\u00fcnk, amit musz\u00e1j megeml\u00edtenem, m\u00e9g ha m\u00e9lyebben nem is megyek most bele.<\/p>\n

Sz\u00f3val a nap szenz\u00e1ci\u00f3ja k\u00e9ts\u00e9gtelen\u00fcl az \u00e1br\u00e1n l\u00e1that\u00f3 kis k\u00e9k-feh\u00e9r szelekci\u00f3. Az ilyesmi minden molekul\u00e1ris laborban robotol\u00f3 ember sz\u00e1m\u00e1ra unalmasnak t\u0171nhet, de ez esetben nagyon nem az. A jobb<\/span> bal oldalon lev\u0151 k\u00e9k kol\u00f3nia ugyanis az els\u0151 szintetikus \u00e9letforma, teljes nev\u00e9n „M. mycoides<\/em> JCVI-syn1.0″. Magyar\u00e1n Craig Venter „megtal\u00e1lta” a szintetikus biol\u00f3gia Szent Gr\u00e1ljainak egyik\u00e9t, \u00e9s l\u00e9trehozott egy mesters\u00e9ges bakt\u00e9riumot.<\/p>\n

<\/p>\n

A dolog sz\u00e9ps\u00e9ghib\u00e1ja persze, hogy mint azt a j\u00f3sz\u00e1g neve is mutatja, ez az\u00e9rt nem teljesen egy tervez\u0151asztalon k\u00e9sz\u00fclt genomot hordoz, hanem a Mycobacterium mycoides <\/em>genomj\u00e1t szintetiz\u00e1lt\u00e1k meg apr\u00f3bb kb 1000 b\u00e1zisp\u00e1ros drabokb\u00f3l, kisebb (j\u00f3pofa) m\u00f3dos\u00edt\u00e1sokkal (pl. id\u00e9zeteket \u00e9s egy email c\u00edmet k\u00f3doltak bele) \u00e9s vitt\u00e9k be egy rokon baci, M. capricolum<\/em> genomj\u00e1ba (az eredeti genetikai \u00e1llom\u00e1nyt elt\u00e1vol\u00edtott\u00e1k). A bakteri\u00e1lis Frankenstein pedig \u00e9letrekelt \u00e9s az\u00f3ta egy k\u00fcl\u00f6nleges M. mycoides<\/em> t\u00f6rzsk\u00e9nt \u00e9li az \u00e9let\u00e9t.<\/p>\n

A feladat \u00edgy le\u00edrva nagyon egyszer\u0171nek t\u0171nhet, de nem az, kb. 15 \u00e9v munk\u00e1ja volt ide\u00e9rni \u00e9s csak az utols\u00f3 l\u00e9p\u00e9s (szintetikus kromosz\u00f3m\u00e1t bevinni a baciba) 3 \u00e9v\u00e9be telt a vil\u00e1g legjobban felszerelt laborj\u00e1ban dolgoz\u00f3 h\u00fasz embernek. (Nem volt eleve trivi\u00e1lis ilyen hossz\u00fa DNS darabot l\u00e9trehozni, amit v\u00e9g\u00fcl \u00e9leszt\u0151 sejtben oldottak meg.) Mindez egyben azt is el\u0151revet\u00edti azt, hogy a v\u00e9gs\u0151 c\u00e9l, adott, komplex feladat elv\u00e9gz\u00e9s\u00e9re tervezett speci\u00e1lis szintetikus bacik el\u0151\u00e1ll\u00edt\u00e1sa m\u00e9g hossz\u00fa-hossz\u00fa \u00e9vekre van.<\/p>\n

A The Guardian<\/em> vide\u00f3j\u00e1ban<\/a> Venter hosszabban is besz\u00e9l a buktat\u00f3kr\u00f3l, a genom-szint\u00e9zis folyamat\u00e1br\u00e1ja pedig itt alul tal\u00e1lhat\u00f3. Ha lesz id\u0151m (valszleg nem :-() majd hosszabban is kives\u00e9zem a cikket.<\/p>\n

\"\"<\/p>\n

\n

Gibson DG, Glass JI, Lartigue C, Noskov VA, Chuang R-Y et al.<\/strong> (2010) Creation of a Bacterial Cell Controlled by a Chemically Synthesized Genome Science<\/em> doi: 10.1126\/science.1190719 <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

A „mir\u0151l \u00edrn\u00e9k, ha \u00e9pp lenne id\u0151m” sorozat \u00fajabb darabj\u00e1hoz \u00e9rt\u00fcnk, amit musz\u00e1j megeml\u00edtenem, m\u00e9g ha m\u00e9lyebben nem is megyek most bele. Sz\u00f3val a nap szenz\u00e1ci\u00f3ja k\u00e9ts\u00e9gtelen\u00fcl az \u00e1br\u00e1n l\u00e1that\u00f3 kis k\u00e9k-feh\u00e9r szelekci\u00f3. Az ilyesmi minden molekul\u00e1ris laborban robotol\u00f3 ember … Egy kattint\u00e1s ide a folytat\u00e1shoz…. →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[124,322,323,85],"class_list":["post-5005913","post","type-post","status-publish","format-standard","hentry","category-biotechnologia","tag-craig_venter","tag-minimalis-sejt","tag-mycobacterium","tag-szintetikus_biologia"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5005913"}],"version-history":[{"count":1,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005913\/revisions"}],"predecessor-version":[{"id":16324771,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005913\/revisions\/16324771"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5005913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5005913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5005913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}