{"id":5005906,"date":"2010-04-20T15:23:03","date_gmt":"2010-04-20T13:23:03","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2010\/04\/20\/hoerzekeny"},"modified":"2010-04-20T15:23:03","modified_gmt":"2010-04-20T13:23:03","slug":"hoerzekeny","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5005906","title":{"rendered":"H\u0151\u00e9rz\u00e9keny"},"content":{"rendered":"<p><img decoding=\"async\" class=\"blossom-image-align-right\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201004\/pit_organ.jpg\" alt=\"\" hspace=\"5\" vspace=\"5\" \/>A cs\u00f6rg\u0151k\u00edgy\u00f3k \u00e9s egyes bo\u00e1k infra\u00e9rz\u00e9kel\u0151 k\u00e9pess\u00e9ge tulajdonk\u00e9ppen ugyanazon a szinten csod\u00e1lt tulajdons\u00e1ga kellene legyen, mint a denev\u00e9rek ultrahangos t\u00e1j\u00e9koz\u00f3d\u00e1sa, hiszen a maga m\u00f3dj\u00e1n \u00e9ppen annyira nem trivi\u00e1lis. F\u0151leg, mivel a k\u00fcl\u00f6nleges szerv egyenesen a l\u00e1t\u00f3k\u00f6zpontba k\u00f6zvet\u00edt inger\u00fcletet, \u00edgy egy\u00e1ltal\u00e1n nem t\u00falz\u00e1s azt \u00e1ll\u00edtani, hogy ezek az \u00e1llatok infr\u00e1ban is l\u00e1tnak.<\/p>\n<p>A h\u0151\u00e9rz\u00e9keny g\u00f6d\u00f6r az orr \u00e9s a szem k\u00f6zt helyezkedik el, a fej mindk\u00e9t oldal\u00e1n &#8211;\u00a0 ezt persze m\u00e1r hossz\u00fa \u00e9vek \u00f3ta tudjuk. De az eddig nem volt vil\u00e1gos, hogy mi is a h\u0151r\u00e9z\u00e9kel\u00e9s molekul\u00e1ris alapja.<\/p>\n<p><!--more--><\/p>\n<p><img decoding=\"async\" class=\"blossom-image-align-right\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201004\/pit_organ.jpg\" alt=\"\" hspace=\"5\" vspace=\"5\" \/>A cs\u00f6rg\u0151k\u00edgy\u00f3k \u00e9s egyes bo\u00e1k infra\u00e9rz\u00e9kel\u0151 k\u00e9pess\u00e9ge tulajdonk\u00e9ppen ugyanazon a szinten csod\u00e1lt tulajdons\u00e1ga kellene legyen, mint a denev\u00e9rek ultrahangos t\u00e1j\u00e9koz\u00f3d\u00e1sa, hiszen a maga m\u00f3dj\u00e1n \u00e9ppen annyira nem trivi\u00e1lis. F\u0151leg, mivel a k\u00fcl\u00f6nleges szerv egyenesen a l\u00e1t\u00f3k\u00f6zpontba k\u00f6zvet\u00edt inger\u00fcletet, \u00edgy egy\u00e1ltal\u00e1n nem t\u00falz\u00e1s azt \u00e1ll\u00edtani, hogy ezek az \u00e1llatok infr\u00e1ban is l\u00e1tnak.<\/p>\n<p>A h\u0151\u00e9rz\u00e9keny g\u00f6d\u00f6r az orr \u00e9s a szem k\u00f6zt helyezkedik el, a fej mindk\u00e9t oldal\u00e1n &#8211;\u00a0 ezt persze m\u00e1r hossz\u00fa \u00e9vek \u00f3ta tudjuk. De az eddig nem volt vil\u00e1gos, hogy mi is a h\u0151r\u00e9z\u00e9kel\u00e9s molekul\u00e1ris alapja.<\/p>\n<p>Ezt kider\u00edtend\u0151, egy csoport olyan g\u00e9neket kerestek, amelyek k\u00fcl\u00f6nlegesen magas szinten fejez\u0151dnek ki a g\u00f6dr\u00f6t beidegz\u0151 <a href=\"http:\/\/en.wikipedia.org\/wiki\/Trigeminal_ganglion\">trigemin\u00e1lis ganglionban (TG)<\/a>. A legizgalmasabb, \u00e9s a legjobb jel\u00f6lt a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Transient_receptor_potential_cation_channel,_member_A1\"><em>TRPA1<\/em> g\u00e9n<\/a> lett, ami egy olyan membr\u00e1nban \u00fcl\u0151 feh\u00e9rj\u00e9t k\u00f3dol, aminek eml\u0151s\u00f6kben az \u00edz\u00e9rz\u00e9sben van szerepe. Konkr\u00e9tabban, az allyl isothiocyanate (AITC) molekul\u00e1t \u00e9rz\u00e9keli, ami a must\u00e1r \u00e9s a wasabi cs\u00edp\u0151s \u00edz\u00e9t adja.<\/p>\n<p>Felder\u00edtend\u0151, hogy val\u00f3ban ez a g\u00e9n felel\u0151s-e a h\u0151\u00e9rz\u00e9kel\u00e9s\u00e9rt, egy hum\u00e1n vesesejtekb\u0151l sz\u00e1rmaz\u00f3 <a href=\"http:\/\/en.wikipedia.org\/wiki\/HEK_cell\">laborat\u00f3riumi sejtvonalban<\/a> fejezt\u00e9k ki, majd a sejteket k\u00fcl\u00f6nb\u00f6z\u0151 h\u0151m\u00e9rs\u00e9kletnek kit\u00e9ve, ellen\u0151rizt\u00e9k, hogy t\u00f6rt\u00e9nik-e jel\u00e1tvitel (ezt a citoplazm\u00e1ban lev\u0151 szabad k\u00e1lcium koncentr\u00e1ci\u00f3j\u00e1nak n\u00f6veked\u00e9se jelzi). Mint az al\u00e1bbi \u00e1br\u00e1n l\u00e1that\u00f3, 32 fok m\u00e1r el\u00e9g volt az aktiv\u00e1ci\u00f3hoz \u00e9s 35-40 fok pedig m\u00e1r magas koncentr\u00e1ci\u00f3j\u00fa AITC-hez hasonl\u00f3 reakci\u00f3t v\u00e1ltott ki. Mindezt \u00f6sszevetve egy texasi patk\u00e1nysikl\u00f3b\u00f3l sz\u00e1rmaz\u00f3 <em>TRPA1<\/em> g\u00e9nnel (ut\u00f3bbinak nincs h\u0151\u00e9rz\u00e9keny g\u00f6dre) j\u00f3l l\u00e1that\u00f3, hogy ez egy remek kis evol\u00faci\u00f3s adapt\u00e1ci\u00f3, hiszen a patk\u00e1nysikl\u00f3 TRPA1 g\u00e9nje h\u0151\u00e9rz\u00e9keny ugyan, de csak l\u00e9nyegesen magasabb h\u0151m\u00e9rs\u00e9klet k\u00e9pes az aktiviz\u00e1l\u00e1s\u00e1ra, mint a cs\u00f6rg\u0151k\u00edgy\u00f3k eset\u00e9ben.<\/p>\n<p><img decoding=\"async\" class=\"blossom-image-align-block\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/201004\/TRPA1-sensitivity.jpg\" alt=\"\" vspace=\"3\" \/><\/p>\n<p>(Az els\u0151 \u00e1bra a <em>Neurophilosophy<\/em> blogr\u00f3l <a href=\"http:\/\/scienceblogs.com\/neurophilosophy\/2010\/03\/wasabi_receptor_is_snakes_infrared_sensor.php\">sz\u00e1rmazik<\/a>.)<\/p>\n<hr \/>\n<p><span style=\"font-size: xx-small;\"><strong>Gracheva EO, Ingolia NT, Kelly YM, Cordero-Morales JF, Hollopeter G, et al.<\/strong> (2010) Molecular basis of infrared detection by snakes. <em>Nature<\/em> <strong>464<\/strong>: 1006-11. <\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>A cs\u00f6rg\u0151k\u00edgy\u00f3k \u00e9s egyes bo\u00e1k infra\u00e9rz\u00e9kel\u0151 k\u00e9pess\u00e9ge tulajdonk\u00e9ppen ugyanazon a szinten csod\u00e1lt tulajdons\u00e1ga kellene legyen, mint a denev\u00e9rek ultrahangos t\u00e1j\u00e9koz\u00f3d\u00e1sa, hiszen a maga m\u00f3dj\u00e1n \u00e9ppen annyira nem trivi\u00e1lis. F\u0151leg, mivel a k\u00fcl\u00f6nleges szerv egyenesen a l\u00e1t\u00f3k\u00f6zpontba k\u00f6zvet\u00edt inger\u00fcletet, \u00edgy egy\u00e1ltal\u00e1n &hellip; <a href=\"https:\/\/criticalbiomass.hu\/?p=5005906\">Egy kattint\u00e1s ide a folytat\u00e1shoz&#8230;. <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5005906","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5005906"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005906\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5005906"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5005906"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5005906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}