{"id":5005715,"date":"2008-03-10T21:11:13","date_gmt":"2008-03-10T20:11:13","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2008\/03\/10\/dagibirka"},"modified":"2008-03-10T21:11:13","modified_gmt":"2008-03-10T20:11:13","slug":"dagibirka","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5005715","title":{"rendered":"Dagibirka"},"content":{"rendered":"<p>\n<img decoding=\"async\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/200803\/texel-sheep.jpg\" align=\"left\" hspace=\"5\" vspace=\"5\" \/>S hogy gyorsan p\u00e9ld\u00e1val is al\u00e1t\u00e1masszam, mit is \u00e9rtettem <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/200803\/\">az el\u0151z\u0151 posztban<\/a> az alatt, hogy <i>&quot;sok morfol\u00f3giai v\u00e1ltoz\u00e1s m\u00e1r meglev\u0151 g\u00e9nek d\u00f3zis\u00e1nak \u00e9s kifejez\u0151d\u00e9si hely\u00e9nek pontosabb szab\u00e1lyoz\u00e1s\u00e1hoz kapcsolhat\u00f3&quot;<\/i> a mikroRNS-ek r\u00e9v\u00e9n, \u00e1lljon itt a <a href=\"http:\/\/en.wikipedia.org\/wiki\/Texel_(sheep)\">Texel birk\u00e1k<\/a> esete.\n<\/p>\n<p>\nA holland Texel sziget\u00e9r\u0151l sz\u00e1rmaz\u00f3 birka fajt\u00e1t h\u00fas\u00e1\u00e9rt kedvelik a teny\u00e9szt\u0151k, ugyanis ezek az \u00e1llatok m\u00e1s fajt\u00e1kn\u00e1l sokkal t\u00f6bb izmot halmoznak fel magukon. \u00c9s egy-egy ilyen birka izmos far\u00e1t eln\u00e9zve egy biol\u00f3gusnak akarva-akaratlanul is a&quot;bully&quot; whippet illetve a feh\u00e9r-k\u00e9k belga <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/200803\/\">ugrik be<\/a>.\n<\/p>\n<p>\nEzekben a kutya illetve teh\u00e9n fajt\u00e1kban az extra izomk\u00f6tegek mind egy <i>myostatin<\/i> <i>(mstn)<\/i> nev\u0171 g\u00e9nben bek\u00f6vetkezett mut\u00e1ci\u00f3khoz k\u00f6thet\u0151k. Eg\u00e9szs\u00e9ges \u00e1llatokban a MSTN feh\u00e9rje az izom\u0151ssejtek oszt\u00f3d\u00e1s\u00e1t szab\u00e1lyozza; hi\u00e1ny\u00e1ban ezek a sejtek extra oszt\u00f3d\u00e1sokon mennek kereszt\u00fcl, ami t\u00f6bb izomrost kialakul\u00e1s\u00e1hoz vezet. A feh\u00e9rje funkci\u00f3ja (legal\u00e1bb is eml\u0151s\u00f6k k\u00f6z\u00f6tt) igencsak konzerv\u00e1ltnak t\u0171nik: ebek \u00e9s szarvasmarh\u00e1k mellett egerekben \u00e9s emberekben is ugyanez a szerepe a MSTN-nak. Logikus volt teh\u00e1t a <i>mstn<\/i> g\u00e9nre f\u00f3kusz\u00e1lni a Texel birk\u00e1k vizsg\u00e1lata sor\u00e1n is.\n<\/p>\n<p>\nAz els\u0151 eredm\u00e9nyek b\u00edztat\u00f3nak t\u0171ntek: a mut\u00e1ci\u00f3 t\u00e9rk\u00e9pez\u00e9se val\u00f3ban a <i>mstn<\/i> poz\u00edci\u00f3j\u00e1hoz k\u00f6t\u00f6tte a fenot\u00edpust. A b\u00f6kken\u0151 csak az volt, hogy a fenti \u00e1llat p\u00e9ld\u00e1kkal ellent\u00e9tben, a birk\u00e1k sz\u00f3banforg\u00f3 g\u00e9nje nem tartalmazott olyan v\u00e1ltoz\u00e1st, ami miatt a feh\u00e9rje m\u0171k\u00f6d\u00e9sk\u00e9ptelen lett volna. Hosszas keresg\u00e9l\u00e9s ut\u00e1n azt\u00e1n f\u00e9ny der\u00fclt arra, hogy a mut\u00e1ci\u00f3 a feh\u00e9rje k\u00f3dol\u00f3 r\u00e9sz m\u00f6g\u00f6tt helyezkedik el. Egy egyetlen b\u00e1zisp\u00e1rnyi v\u00e1ltoz\u00e1sr\u00f3l van sz\u00f3, aminek k\u00f6vetkezt\u00e9ben egyszerre k\u00e9t izomspecifikus miRNS (<i>mir1<\/i> \u00e9s <i>mir206<\/i>) is k\u00e9pess\u00e9 v\u00e1lik a Texel birk\u00e1k <i>mstn<\/i> mRNS-\u00e9hez k\u00f6t\u0151dni, megg\u00e1tolva annak \u00e1t\u00edr\u00f3d\u00e1s\u00e1t. \u00cdgy hi\u00e1ba hib\u00e1tlan a feh\u00e9rje k\u00f3dol\u00f3 szekvenci\u00e1ja, mert v\u00e9gs\u0151 soron sosem lesz bel\u0151le funkcion\u00e1lis term\u00e9k. A birka izmok pedig csak n\u0151nek \u00e9s n\u0151nek. \u00a0 \u00a0 \u00a0\n<\/p>\n<hr \/>\n<p><font size=\"1\"><br \/>\n<strong>Clop A, Marcq F, Takeda H, Pirottin D, Tordoir X, et al.<\/strong> A mutation creating a potential illegitimate microRNA target site in the <i>myostatin<\/i> gene affects muscularity in sheep. <i>Nat Genet<\/i> <strong>38(7)<\/strong>: 813-818.<br \/>\n<\/font><\/p>\n","protected":false},"excerpt":{"rendered":"<p>S hogy gyorsan p\u00e9ld\u00e1val is al\u00e1t\u00e1masszam, mit is \u00e9rtettem az el\u0151z\u0151 posztban az alatt, hogy &quot;sok morfol\u00f3giai v\u00e1ltoz\u00e1s m\u00e1r meglev\u0151 g\u00e9nek d\u00f3zis\u00e1nak \u00e9s kifejez\u0151d\u00e9si hely\u00e9nek pontosabb szab\u00e1lyoz\u00e1s\u00e1hoz kapcsolhat\u00f3&quot; a mikroRNS-ek r\u00e9v\u00e9n, \u00e1lljon itt a Texel birk\u00e1k esete. A holland Texel &hellip; <a href=\"https:\/\/criticalbiomass.hu\/?p=5005715\">Egy kattint\u00e1s ide a folytat\u00e1shoz&#8230;. <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5005715","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005715","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5005715"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005715\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5005715"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5005715"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5005715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}