{"id":5005657,"date":"2007-10-08T16:02:38","date_gmt":"2007-10-08T14:02:38","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2007\/10\/08\/orvosi_nobel_dij_2008"},"modified":"2007-10-08T16:02:38","modified_gmt":"2007-10-08T14:02:38","slug":"orvosi_nobel_dij_2008","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5005657","title":{"rendered":"Orvosi Nobel d\u00edj &#8211; 2007"},"content":{"rendered":"<p>\n<img decoding=\"async\" src=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/200710\/hom-rec_mice.jpg\" align=\"left\" vspace=\"3\" \/>Az <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/medicine\/laureates\/2007\/\">idei orvosi Nobel d\u00edj<\/a> meg\u00e9rdemelt helyre ker\u00fclt, ugyanis a h\u00e1rom d\u00edjazott \u00fariember munk\u00e1ja forradalmos\u00edtotta az eg\u00e9r-genetik\u00e1t, s ezen kereszt\u00fcl a molekul\u00e1ris biol\u00f3gia nagyr\u00e9sz\u00e9t is.\n<\/p>\n<p>\n<a href=\"http:\/\/capecchi.genetics.utah.edu\/capecchi.html\">Mario Capecchi<\/a>, <a href=\"http:\/\/www.cardiff.ac.uk\/biosi\/research\/genetics\/staff\/evans.html\">Martin Evans<\/a> \u00e9s <a href=\"http:\/\/www.pathology.unc.edu\/common\/smithies.htm\">Oliver Smithies<\/a> \u00fatt\u00f6r\u0151 munk\u00e1j\u00e1nak k\u00f6sz\u00f6nhetj\u00fck, hogy manaps\u00e1g a legt\u00f6bb egerekkel foglalkoz\u00f3 laborban transzg\u00e9nikus kis r\u00e1gcs\u00e1l\u00f3k rohang\u00e1lnak, amelyek fluoreszcensen vil\u00e1g\u00edtanak a legv\u00e1ratlanabb helyeken, vagy egyes g\u00e9njeiket csak bizonyos sejtjeikben vesztik el.\n<\/p>\n<p>\nA ma alkalmazott elj\u00e1r\u00e1s l\u00e9nyege, hogy egy eg\u00e9r \u0151ssejtvonal sejtjeibe egy olyan DNS szakaszt juttatunk, amely az \u00e1ltalunk bejuttatni k\u00edv\u00e1nt genetikai \u00e1llom\u00e1nyt tartalmazza, olyan szakaszokkal hat\u00e1rolva, amelyek az eg\u00e9r genomban is el\u0151fordulnak egym\u00e1s szomsz\u00e9ds\u00e1g\u00e1ban. A homol\u00f3g rekombin\u00e1ci\u00f3nak nevezett esem\u00e9ny ezut\u00e1n k\u00e9pes az eg\u00e9r, eml\u00edtett szakaszok k\u00f6z\u00f6tt rejl\u0151 saj\u00e1t DNS-\u00e9t kicser\u00e9lni az \u00e1ltalunkbejuttatotra, \u00e9s voil\u00e1 megvan a transzg\u00e9nikus \u0151ssejtvonal. Ezeket a sejteket m\u00e1r &quot;csak&quot; egy korai st\u00e1diumban lev\u0151 eg\u00e9rembri\u00f3ba kell bejuttatni, \u00e9s szor\u00edtani, hogy a cs\u00edravonal ezekb\u0151l (is) j\u00f6jj\u00f6n l\u00e9tre, \u00e9s a k\u00f6vetkez\u0151 gener\u00e1ci\u00f3b\u00e1n m\u00e1r vid\u00e1man futk\u00e1roz\u00f3, kis hordoz\u00f3kkal lesz\u00fcnk meg\u00e1ldva.\n<\/p>\n<p>\nTudom, nem hangzik trivi\u00e1lisan, de ma m\u00e1r-m\u00e1r nagy\u00fczemi szinten megy a folyamat. B\u0151vebben <a href=\"http:\/\/www.bio.davidson.edu\/Courses\/genomics\/method\/homolrecomb.html\">itt<\/a> lehet err\u0151l olvasni, ill. a Sv\u00e9d Akad\u00e9mia <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/medicine\/laureates\/2007\/press.html\">indokl\u00e1s\u00e1ban<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Az idei orvosi Nobel d\u00edj meg\u00e9rdemelt helyre ker\u00fclt, ugyanis a h\u00e1rom d\u00edjazott \u00fariember munk\u00e1ja forradalmos\u00edtotta az eg\u00e9r-genetik\u00e1t, s ezen kereszt\u00fcl a molekul\u00e1ris biol\u00f3gia nagyr\u00e9sz\u00e9t is. Mario Capecchi, Martin Evans \u00e9s Oliver Smithies \u00fatt\u00f6r\u0151 munk\u00e1j\u00e1nak k\u00f6sz\u00f6nhetj\u00fck, hogy manaps\u00e1g a legt\u00f6bb egerekkel &hellip; <a href=\"https:\/\/criticalbiomass.hu\/?p=5005657\">Egy kattint\u00e1s ide a folytat\u00e1shoz&#8230;. <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5005657","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005657","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5005657"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005657\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5005657"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5005657"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5005657"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}