{"id":5005480,"date":"2006-10-04T12:43:27","date_gmt":"2006-10-04T10:43:27","guid":{"rendered":"https:\/\/criticalbiomass.blog.hu\/2006\/10\/04\/s_orvosi_s_nobel_dij_2006"},"modified":"2006-10-04T12:43:27","modified_gmt":"2006-10-04T10:43:27","slug":"s_orvosi_s_nobel_dij_2006","status":"publish","type":"post","link":"https:\/\/criticalbiomass.hu\/?p=5005480","title":{"rendered":"<s>Orvosi<\/s> Nobel d\u00edj &#8211; 2006"},"content":{"rendered":"<p><img src=\"http:\/\/library.thinkquest.org\/TQ0313040\/images\/ANobel.gif\" align=\"left\" hspace=\"5\" vspace=\"5\" \/><\/p>\n<p>\n<a href=\"http:\/\/nobelprize.org\/nobel_prizes\/medicine\/laureates\/2006\/\">Felsz\u00e1llt a f\u00fcst<\/a>: az idei orvosi Nobel d\u00edjat a sv\u00e9d akad\u00e9mia <a href=\"http:\/\/med.stanford.edu\/profiles\/Andrew_Fire\/\"><span class=\"h3teaser\">Andrew Z. Fire<\/span><\/a><span class=\"h3teaser\"><\/span><br \/>\n-nak \u00e9s <a href=\"http:\/\/www.hhmi.org\/research\/investigators\/mello_bio.html\">Craig C. Mello<\/a><span class=\"h3teaser\">-nak adta, az <strong>RNS-interferencia (RNAi)<\/strong> felfedez\u00e9s\u00e9\u00e9rt.<\/span>\n<\/p>\n<p>\n\u00c9s, hogy azmegmiafene, egy <a href=\"http:\/\/criticalbiomass.blog.hu\/media\/image\/200610\/\">kor\u00e1bbi postb\u00f3l<\/a>:\n<\/p>\n<p>\n&quot;Az <a href=\"http:\/\/www.nature.com\/focus\/rnai\/animations\/animation\/animation.htm\" title=\"RNAi anim\u00e1ci\u00f3  @ Nature\" target=\"-\" rel=\"noopener\">RNS-interferencia (RNAi)<\/a> [&#8230;] egy p\u00e1r \u00e9ve felfedezett jelens\u00e9g, egy<br \/>\nuniverz\u00e1lis szab\u00e1lyoz\u00f3 mechanizmus, amely azon alapul, hogy egy<br \/>\nbizonyos protein (Dicer) felismeri a kett\u0151s sz\u00e1l\u00fa RNS spir\u00e1lt \u00e9s azt<br \/>\nlebontva egy \u00f6nkataliz\u00e1l\u00f3 folyamatot ind\u00edt el. Ugyanis a duplex<br \/>\nlebont\u00e1s\u00e1val keletkez\u0151 kis k\u00e9tsz\u00e1l\u00fa RNS darabok (siRNA) egy m\u00e1sik<br \/>\nfeh\u00e9rj\u00e9hez (Slicer) kapcsol\u00f3dva egysz\u00e1l\u00fav\u00e1 alakulnak, egy RNAi<br \/>\nsilencing complex-t (RISC) hozva l\u00e9tre. A RISC k\u00e9pes felismerni a kis<br \/>\nRNS darabbal komplementer mRNS molekul\u00e1kat \u00e9s azokhoz k\u00f6t\u0151dve<br \/>\nkataliz\u00e1lni lebont\u00e1sukat. R\u00e1ad\u00e1sul ez az epigenetikus v\u00e1ltoz\u00e1s<br \/>\nbizony\u00edtottan \u00f6r\u00f6kl\u0151d\u0151.&quot;\n<\/p>\n<p>\n<em>Update<\/em>:\n<\/p>\n<p>\nA <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/chemistry\/laureates\/2006\/\">k\u00e9miai Nobel d\u00edjat<\/a> pedig (lassan szinte hagyom\u00e1nyos m\u00f3don) biok\u00e9miai kutat\u00e1s kapta: <a href=\"http:\/\/kornberg.stanford.edu\/\">Roger Kornberg<\/a> az eukari\u00f3ta transzkripci\u00f3s appar\u00e1tus molekul\u00e1ris le\u00edr\u00e1s\u00e1\u00e9rt. (Konyhanyelvebben: milyen feh\u00e9rj\u00e9k \u00e9s mik\u00e9ppen kapcsol\u00f3dnak ahhoz, hogy az eukari\u00f3t\u00e1kban egy-egy g\u00e9n \u00e1t\u00edr\u00f3djon.)\n<\/p>\n<p>\n<font size=\"1\"><br \/>\n(\u00c9rdekess\u00e9g-csemege: Kornbergnek m\u00e1r az <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/medicine\/laureates\/1959\/index.html\">apja is <\/a>Nobel d\u00edjat nyert 1959-ben a DNS \u00e9s az RNS szint\u00e9zis megval\u00f3s\u00edt\u00e1s\u00e1\u00e9rt. Nem is tudom, hogy a <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/chemistry\/laureates\/1911\/index.html\">Curie<\/a> <a href=\"http:\/\/nobelprize.org\/nobel_prizes\/chemistry\/laureates\/1935\/index.html\">csal\u00e1don<\/a> k\u00edv\u00fcl van-e m\u00e1s p\u00e9lda ilyen &quot;d\u00edjhalmoz\u00e1sra&quot;. :-))<br \/>\n<\/font><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Felsz\u00e1llt a f\u00fcst: az idei orvosi Nobel d\u00edjat a sv\u00e9d akad\u00e9mia Andrew Z. Fire -nak \u00e9s Craig C. Mello-nak adta, az RNS-interferencia (RNAi) felfedez\u00e9s\u00e9\u00e9rt. \u00c9s, hogy azmegmiafene, egy kor\u00e1bbi postb\u00f3l: &quot;Az RNS-interferencia (RNAi) [&#8230;] egy p\u00e1r \u00e9ve felfedezett jelens\u00e9g, egy &hellip; <a href=\"https:\/\/criticalbiomass.hu\/?p=5005480\">Egy kattint\u00e1s ide a folytat\u00e1shoz&#8230;. <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005480"}],"collection":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5005480"}],"version-history":[{"count":0,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=\/wp\/v2\/posts\/5005480\/revisions"}],"wp:attachment":[{"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5005480"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5005480"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/criticalbiomass.hu\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5005480"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}